BnO-PEG6-OH |
| Catalog No.GC62535 |
BnO-PEG6-OH는 항체-약물 접합체(ADC) 합성에 사용되는 절단 불가능한 6단위 PEG ADC 링커입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 24342-68-5
Sample solution is provided at 25 µL, 10mM.
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BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BnO-PEG6-OH is also a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Shaoyun Xiang, et al. Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses there. Patent WO2016197946A1.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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