Boc-C16-COOH |
| Catalog No.GC63924 |
Boc-C16-COOH는 항체-약물 접합체(ADC) 합성에 사용되는 절단 불가능한 ADC 링커입니다. Boc-C16-COOH는 또한 PROTAC의 합성에 사용할 수 있는 알킬 사슬 기반 PROTAC 링커입니다. CRBN의 경우 414nM. PROTAC KRAS G12C 분해자-1은 CRBN/KRASG12C 이량체화를 유도하고 리포터 세포에서 GFP-KRASG12C를 분해합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 843666-40-0
Sample solution is provided at 25 µL, 10mM.
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Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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