BRD7-IN-1 |
| Catalog No.GC34505 |
BI7273(BRD7/9 억제제)의 변형된 유도체인 BRD7-IN-1은 링커를 통해 VHL 리간드에 결합하여 PROTAC VZ185(각각 4.5 및 1.8nM의 DC50을 갖는 BRD7/9에 대한 VZ185)를 형성합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2448414-48-8
Sample solution is provided at 25 µL, 10mM.
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BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1]. BRD7, BRD9[1]
[1]. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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