Brevetoxin B (Synonyms: Brevetoxin 2, BTX-B, GbTx-2, PbTx-2) |
| Catalog No.GC42976 |
브레베톡신 B(브레베톡신-2; PbTx-2)는 카레니아 종 및 기타 과편모조류에 의해 생성되는 폴리케타이드 신경독입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79580-28-2
Sample solution is provided at 25 µL, 10mM.
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Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
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