Bromoacetamido-PEG4-acid |
| Catalog No.GC65705 |
Bromoacetamido-PEG4-acid는 PROTAC 합성에 사용할 수 있는 PEG 기반 PROTAC 링커입니다. 821d96072c2d58d8970e76f526b0f6b8Bromoacetamido-PEG4-산은 또한 항체-약물 접합체(ADC)의 합성에 사용되는 절단 가능한 4단위 PEG ADC 링커입니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 1807518-67-7
Sample solution is provided at 25 µL, 10mM.
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Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
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