BTRX-335140 (Synonyms: CYM-53093) |
| Catalog No.GC39354 |
BTRX-335140(CYM-53093)은 선택적 및 경구 활성 κ 오피오이드 수용체(KOR) 길항제이며, 각각 0.8 nM, 110 nM 및 6500 nM의 IC50 값으로 κOR, μOR 및 δOR에 대한 길항제 활성을 갖는다.
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Cas No.: 2244614-14-8
Sample solution is provided at 25 µL, 10mM.
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BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively.BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].
[1]. Guerrero M, et al. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). J Med Chem. 2019 Feb 28;62(4):1761-1780.
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