Casimersen (Synonyms: SRP-4045) |
| Catalog No.GC64361 |
Casimersen(SRP-4045)은 포스포로디아미데이트 모르폴리노 올리고머 서브클래스의 안티센스 올리고뉴클레오티드입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1422958-19-7
Sample solution is provided at 25 µL, 10mM.
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Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD)[1].
Exon 45 skipping is intended to allow for production of an internally truncated dystrophin protein in patients with genetic mutations that are amenable to exon 45 skipping[2].
[1]. Shirley M. Casimersen: First Approval. Drugs. 2021;81(7):875-879. [2]. Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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