CAY10444 (Synonyms: BML-241) |
| Catalog No.GC18757 |
CAY10444(BML-241)는 스핑고신-1-포스페이트 3(S1P3) 길항제입니다. CAY10444는 S1P3 수용체를 발현하는 HeLa 세포에서 Ca2+의 S1P 유도 증가를 37% 억제합니다.
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Cas No.: 298186-80-8
Sample solution is provided at 25 µL, 10mM.
A family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned.[1],[2] S1P3/EDG3 is a member of this family that is widely expressed in many tissues, signaling via the ERK-½ and PLC/IP3 pathways. CAY10444 is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 µM.[3]
Reference:
[1]. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta 1582(1-3), 72-80 (2002).
[2]. Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews 54, 265-269 (2002).
[3]. Koide, Y., Hasegawa, T., Takahashi, A., et al. Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. Journal of Medicinal Chemistry 45, 4629-4638 (2002).
| Cas No. | 298186-80-8 | SDF | |
| Synonyms | BML-241 | ||
| Chemical Name | 2-undecyl-thiazolidine-4-carboxylic acid | ||
| Canonical SMILES | [H]N1C(CCCCCCCCCCC)SC[C@H]1C(O)=O | ||
| Formula | C15H29NO2S | M.Wt | 287.5 |
| Solubility | 0.5mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4783 mL | 17.3913 mL | 34.7826 mL |
| 5 mM | 0.6957 mL | 3.4783 mL | 6.9565 mL |
| 10 mM | 0.3478 mL | 1.7391 mL | 3.4783 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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