CCR7 Ligand 1 (Synonyms: CCR7-Cmp2105) |
| Catalog No.GC39356 |
CCR7 리간드 1(CCR7-Cmp2105)은 알로스테릭 리간드이자 3 nM의 Kd를 갖는 인간 CC 케모카인 수용체 7(CCR7)에 대한 길항제입니다. CCR7 리간드 1, 티아디아졸-디옥사이드 리간드는 7.3μM의 IC50으로 CCL19에 의한 활성화에 대한 반응으로 어레스틴 결합을 억제합니다.
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Cas No.: 681514-83-0
Sample solution is provided at 25 µL, 10mM.
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CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1].
[1]. Jaeger K, et al. Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7. Cell. 2019 Aug 22;178(5):1222-1230.e10.
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