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Cefoperazone (sodium salt) (Synonyms: Cefoneg,Cefosint,CP 52,640-2,Perocef)

Catalog No.GC15412

반합성 세팔로스포린인 Cefoperazone(나트륨염)(CP 52640-2)은 광범위한 항균 활성을 가지고 있습니다.

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Cefoperazone (sodium salt) Chemical Structure

Cas No.: 62893-20-3

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10g
US$201.00
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Sample solution is provided at 25 µL, 10mM.

Description of Cefoperazone (sodium salt)

Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

In vitro: There was only a small spread between the minimum inhibitory concentrations and the minimum bactericidal concentrations of cefoperazone and a significant decrease in activity with an increase in inoculum size. Cefoperazone is relatively stable to hydrolysis to β-lactamases produced by gram-negative bacteria. Relative rates of hydrolysis of cefoperazone by cephalosporinases were 7.0 to 0.01[1]. In 50 strains of N. gonorrhoeae, the MIC50 of cefoperazone was ≤ 0.004-0.06 μg/ml [2].

In vivo: In four patients with cholelithiasis and one patient with carcinoma of the head of the pancreas, all of whom had normal renal functions, cefoperazone was intravenously administrated. In common duct bile, the maximum concentrations of cefoperazone ranged from 373.4 to 3,100 μg/ml while the concentrations ranged from 6.8 to 680 μg/ml in gall bladder bile. Cefoperazone concentrations of the gall bladder wall ranged from 16.8 to 48.0 μg/g [3].

References:
[1] Matsubara N, Minami S, Muraoka T, et al.  In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin[J]. Antimicrobial agents and chemotherapy, 1979, 16(6): 731-735.
[2] Baker C N, Thornsberry C, Jones R N.  In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains[J]. Antimicrobial agents and chemotherapy, 1980, 17(4): 757-761.
[3] Nakamura T, Hashimoto I, Sawada Y, et al.  Cefoperazone concentrations in bile and gall bladder wall after intravenous administration[J]. Antimicrobial agents and chemotherapy, 1980, 18(6): 980-982.

Chemical Properties of Cefoperazone (sodium salt)

Cas No. 62893-20-3 SDF
Synonyms Cefoneg,Cefosint,CP 52,640-2,Perocef
Chemical Name (6R,7R)-7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
Canonical SMILES CCN(CCN(C(N[C@H](C1=CC=C(O)C=C1)C(N[C@@H]2C(N3[C@]2([H])SCC(CSC4=NN=NN4C)=C3C([O-])=O)=O)=O)=O)C5=O)C5=O.[Na+]
Formula C25H26N9O8S2 • Na M.Wt 667.7
Solubility ≤20mg/ml in DMSO;15mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Cefoperazone (sodium salt)

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1 mg 5 mg 10 mg
1 mM 1.4977 mL 7.4884 mL 14.9768 mL
5 mM 0.2995 mL 1.4977 mL 2.9954 mL
10 mM 0.1498 mL 0.7488 mL 1.4977 mL
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In vivo Formulation Calculator (Clear solution) of Cefoperazone (sodium salt)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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