Cortistatin 14 (Synonyms: CST-14, human, rat) |
| Catalog No.GC12835 |
신경 억제 및 수면 조절 특성을 가진 신경 펩티드인 코르티스타틴 14(CST-14, 인간, 쥐)는 5개의 복제된 소마토스타틴 수용체(SSTR) 및 그렐린 수용체 모두에 결합하여 생물학적 활성을 발휘하고 피질 내에서 GABA와 공존할 수 있습니다. 그리고 해마.
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Cas No.: 193829-96-8
Sample solution is provided at 25 µL, 10mM.
Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells).[1],[2] It is expressed in GABAergic interneurons in the cortex and hippocampus.[2],[3] Cortistatin-14 competitively inhibits hexarelin binding to human growth hormone secretagogue receptors (GHS-R) in pituitary membranes (Ki = 0.54 μM).[4] It also activates the human Mas-related gene receptor MrgX2 expressed in HEK293 cells leading to quantifiable GTP-γS binding to the G protein subunit Gαο (EC50 = 1.3 μM).[5] Cortistatin-14 (0.01-1 μM), similarly to somatostatin-14, completely inhibits thyrotropin-releasing hormone, and partially inhibits vasoactive intestinal peptide, stimulation of cAMP production in GH4 cells.3 In mice, cortistatin-14 dose-dependently (0.05-5 μg, i.c.v.) impairs memory retention when administered after foot shock avoidance training.[6] Cortistatin-14 (40-320 μg/kg, s.c.) dose-dependently reduces growth hormone secretion in rats by greater than 80% after 10 minutes when administered at doses of 40-320 µg/kg.[7]
Reference:
[1]. Criado, J.R., Li, H., Jiang, X., et al. Structural and compositional determinants of cortistatin activity. J. Neurosci. Res. 56(6), 611-619 (1999).
[2]. Spier, A.D., and de Lecea, L. Cortistatin: A member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. Brain Res. Rev. 33(2-3), 228-241 (2000).
[3]. de Lecea, L., Criado, J.R., Prospero-Garcia, O., et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381(6579), 242-245 (1996).
[4]. Deghenghi, R., Papotti, M., Ghigo, E., et al. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. J. Endocrinol. Invest. 24(1), RC1-RC3 (2001).
[5]. Burstein, E.S., Ott, T.R., Feddock, M., et al. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. Br. J. Pharmacol. 147(1), 73-82 (2006).
[6]. Flood, J.F., Uezu, K., and Morley, J.E. The cortical neuropeptide, cortistatin-14, impairs post-training memory processing. Brain Res. 775(1-2), 250-252 (1997).
[7]. Deghenghi, R., Avallone, R., Torsello, A., et al. Growth hormone-inhibiting activity of cortistatin in the rat. J. Endocrinol. Invest. 24(11), RC31-RC33 (2001).
| Cas No. | 193829-96-8 | SDF | |
| Synonyms | CST-14, human, rat | ||
| Chemical Name | (S)-2-((Z)-(((4R,5Z,7S,8E,10S,11Z,13S,14Z,16S,17Z,19S,20Z,22S,23Z,25S,26Z,28S,29Z,31S,32Z,34S,35Z,37R)-22-((1H-indol-3-yl)methyl)-19,34-bis(4-aminobutyl)-13,25,28-tribenzyl-6,9,12,15,18,21,24,27,30,33,36-undecahydroxy-37-((Z)-(hydroxy((S)-pyrrolidin-2-yl) | ||
| Canonical SMILES | C[C@](O)([H])[C@@]1([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N\[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CCCCN)([H])CSSC[C@@](/N=C(O)/[C@]2([H])CCCN2)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/1)([H]) | ||
| Formula | C81H113N19O19S2 | M.Wt | 1721.03 |
| Solubility | 1mg/mL in water | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.581 mL | 2.9052 mL | 5.8105 mL |
| 5 mM | 0.1162 mL | 0.581 mL | 1.1621 mL |
| 10 mM | 0.0581 mL | 0.2905 mL | 0.581 mL |
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- Purity: >99.50%
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Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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