CP 424174 |
| Catalog No.GC50342 |
CP 424174는 IC50이 210nM인 IL-1β 처리에 대한 가역적 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 210825-31-3
Sample solution is provided at 25 µL, 10mM.
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Inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID:11561079 |Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID:26422006
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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