CP 93,129

CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT_1B.^[1] It selectively binds to 5-HT_1B over 5-HT_1A, 5-HT_1C, 5-HT_1D, and 5-HT₂ receptors (K_is = 0.0081, 1.5, 2.9, 1.1, and 7.2 µM, respectively). CP 93,129 (5.4 µM) inhibits potassium-induced GABA release from rat globus pallidus slices.^[2] It reverses akinesia in a rat model of Parkinson’s disease induced by reserpine when administered intrapallidally at doses of 110 and 220 nmol/animal. CP 93,129 reduces food intake in rats when infused into the pons parabrachial nucleus or the paraventricular nucleus (PVN) of the hypothalamus (ED₅₀s = 1 and 50 nmol/animal, respectively).^[3] It also reduces the frequency of pursuits, tail rattles, threats, and attack bites in a resident-intruder test in mice.^[4]

References:
[1].Koe, B.K., Nielsen, J.A., Macor, J.E., et al.Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253Drug Dev. Res.26(3)241-250(1992).
[2].Chadha, A., Sur, C., Atack, J., et al.The 5HT1B receptor agonist, CP-93129, inhibits [3H]-GABA release from rat globus pallidus slices and reverses akinesia following intrapallidal injection in the reserpine-treated ratBr. J. Pharmacol.130(8)1927-1932(2000).
[3].Lee, M.D., Aloyo, V.J., Fluharty, S.J., et al.Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in ratsPsychopharmacology (Berl.)136(3)304-307(1997).
[4].Bannai, M., Fish, E.W., Faccidomo, S., et al.Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of micePsychopharmacology (Berl.)193(2)295-304(2007).