CRN04894 |
| Catalog No.GC71439 |
CRN04894 (화합물 17h) 는 경구용 활성 MC2R 옹색제로, 부신피질호르몬(ACTH) 자극을 촉진하는 쥐피질케톤 분비 모델에서 체내 치료 효과를 나타낸다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2392970-97-5
Sample solution is provided at 25 µL, 10mM.
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CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with KB values of 0.34 nM and 0.23 nM, respsectively.
CRN04894 (compound 17h) (3, 30 mg/kg; po; single dose) dose-dependently reduces corticosterone secretion levels in an ACTH-stimulated male rat model[1].
References:
[1]. Kim SH, et al. Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485.
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