CRN04894 |
| Catalog No.GC71439 |
CRN04894 (화합물 17h) 는 경구용 활성 MC2R 옹색제로, 부신피질호르몬(ACTH) 자극을 촉진하는 쥐피질케톤 분비 모델에서 체내 치료 효과를 나타낸다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2392970-97-5
Sample solution is provided at 25 µL, 10mM.
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CRN04894 (compound 17h) (3, 30 mg/kg; po; single dose) dose-dependently reduces corticosterone secretion levels in an ACTH-stimulated male rat model[1].
References:
[1]. Kim SH, et al. Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485.
| Cas No. | 2392970-97-5 | SDF | |
| Formula | C33H42F3N5O3 | M.Wt | 613.71 |
| Solubility | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.6294 mL | 8.1472 mL | 16.2943 mL |
| 5 mM | 0.3259 mL | 1.6294 mL | 3.2589 mL |
| 10 mM | 0.1629 mL | 0.8147 mL | 1.6294 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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