Cyclophosphamide-d4 |
| Catalog No.GC47148 |
Cyclophosphamide-d4는 Cyclophosphamide로 표시된 중수소입니다. 사이클로포스파미드는 면역억제제인 항종양 활성을 갖는 질소 머스타드와 화학적으로 관련된 합성 알킬화제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 173547-45-0
Sample solution is provided at 25 µL, 10mM.
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Cyclophosphamide-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of cyclophosphamide by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders.1,2 In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug and is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.3,4
1.Yildirim-Toruner, C., and Diamond, B.Current and novel therapeutics in the treatment of systemic lupus erythematosusJ. Allergy Clin. Immunol.127(2)303-314(2011) 2.Appel, G.B.New and future therapies for lupus nephritisCleve. Clin. J. Med.79(2)134-140(2012) 3.Ahmed, A.R., and Hombal, S.M.Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical usesJ. Am. Acad. Dermatol.11(6)1115-1126(1984) 4.Bischoff, P.L., Holl, V., Coelho, D., et al.Apoptosis at the interface of immunosuppressive and anticancer activities: The examples of two classes of chemical inducers, oxysterols and alkylating agentsCurr. Med. Chem.7(7)693-713(2000)
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