Cytostatin |
| Catalog No.GC43360 |
Cytostatin은 유망한 항종양 활성을 가진 PP2A의 강력하고 선택적인 억제제입니다. Cytostatin은 또한 세포외 기질에 대한 세포 부착의 억제제이며 세포 사멸을 유도합니다. Cytostatin은 천연 제품의 fosriecin 계열에 속합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 682329-63-1
Sample solution is provided at 25 µL, 10mM.
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Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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