D-Proline, 4-hydroxy-, methyl ester hydrochloride |
| Catalog No.GC66216 |
D-Proline, 4-hydroxy-, methyl ester hydrochloride는 항체-약물 접합체(ADC)의 합성에 사용되는 절단 불가능한 ADC 링커입니다. 821d96072c2d58d8970e76f526b0f6b8D-Proline, 4-hydroxy-, methyl ester hydrochloride는 PROTAC[2] 합성에 사용할 수 있는 알킬 사슬 기반 PROTAC 링커이기도 합니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114676-59-4
Sample solution is provided at 25 µL, 10mM.
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D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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