DC07090 dihydrochloride |
| Catalog No.GC70549 |
DC07090 dihydrochloride 는 저독성, 강력성, 가역성, 경쟁성 비펩티드기인 장내 바이러스 71 3C 프로테아제 억제제로서 IC50과 Ki 값은 각각 21.72 μM과 23.29 μM이다.
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Cas No.: 1158264-37-9
Sample solution is provided at 25 µL, 10mM.
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DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM[1].
References:
[1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991.
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