DC432 (trifluoroacetate salt) |
| Catalog No.GC90563 |
NTMT1의 펩타이드 억제제
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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DC432 is a cell-permeable peptide inhibitor of N-terminal Xaa-Pro-Lys N-metltransferase 1 (NTMT1; IC50 = 0.054 µM).1 It binds to NTMT1 and NTMT2 (Kds = 0.3 and 1 µM, respectively) and inhibits N-terminal dimetlation of regulator of chromosome condensation 1 (RCC1) by NTMT1 in a cell-free assay when used at concentrations of 10 and 50 µM. DC432 (100 µM) reduces trimetlation of the RCC1 SPKRIA motif in HCT116 cells.
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