Demethylcantharidate disodium |
| Catalog No.GC62537 |
내인성 대사 산물인 Demethylcantharidate disodium은 ER 스트레스를 통해 간세포 암종 세포에서 세포 사멸을 유도합니다.
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Cas No.: 129-67-9
Sample solution is provided at 25 µL, 10mM.
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Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1].
Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1].Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1].
Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1].
[1]. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15.
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