>>DiaPep277

DiaPep277

Catalog No.GC70243

DiaPep277는 HSP60의 위치 437-460에서 유래한 24개의 아미노산 펩타이드입니다.

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DiaPep277 Chemical Structure

Cas No.: 179822-83-4

Size 가격 재고 수량
1 mg
US$68.00
재고 있음
5 mg
US$172.00
재고 있음
10 mg
US$224.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes.

DiaPep277 (50 μg; i.p.; single dosage) causes strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses[2].

References:
[1]. Eldor R, et al. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev. 2009 May;25(4):316-20.
[2]. Elias D, et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3088-91.

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