Dynole 2-24 |
| Catalog No.GC66056 |
Dynole 2-24는 인돌 기반 다이나민 GTPase 억제제(IC50=0.56 μ 다이나민 I에 대한 M)입니다. 821d96072c2d58d8970e76f526b0f6b8Dynole 2-24는 무독성이며 시험관 내 및 세포 내에서 dynamin I 및 II에 대해 증가된 효능을 나타냅니다(IC₅₀(CME)=1.9 μM). 821d96072c2d58d8970e76f526b0f6b8Dynole 2-24는 또한 dynamin I에 대해 4.4배의 선택성을 나타냅니다. Dynole 2-24는 클라트린 매개 엔도사이토시스의 활성 세포 내 억제제입니다. 821d96072c2d58d8970e76f526b0f6b8CME: 클라트린 매개 엔도사이토시스821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416313-72-8
Sample solution is provided at 25 µL, 10mM.
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Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC??(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis
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