EF24 |
| Catalog No.GC64496 |
EF24는 구강 편평 세포 암종(OSCC)에서 MAPK/ERK 신호 전달 경로의 비활성화를 통해 더 큰 항종양 효능과 경구 생체이용률을 가진 커큐민 유사체입니다. EF24 처리는 활성화된 카스파제 3 및 9의 수준을 증가시키고 MEK1 및 ERK의 인산화된 형태를 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 342808-40-6
Sample solution is provided at 25 µL, 10mM.
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EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].
[1]. Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834. [2]. Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.
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