Efaproxiral Sodium |
| Catalog No.GC14586 |
에파프록시랄 나트륨(RSR13 나트륨)은 헤모글로빈(Hb)의 합성 알로스테릭 변형제이며, Hb-산소(O2) 결합 친화도를 감소시키고 방사선 요법 동안 저산소 종양의 산소화를 향상시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170787-99-2
Sample solution is provided at 25 µL, 10mM.
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Efaproxiral sodium is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
References:
[1]. Stea B, et al. Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases. Br J Cancer. 2006 Jun 19;94(12):1777-1784.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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