EFdA-TP tetrasodium |
| Catalog No.GC70800 |
EFdA-TP tetrasodium 는 강력한 뉴클레오티드 역전사 효소 (RT) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2883783-00-2
Sample solution is provided at 25 µL, 10mM.
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EFdA-TP tetrasodium (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetrasodium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP tetrasodium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].
References:
[1]. Martin Markowitz, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor. Curr Opin HIV AIDS. 2018 Jul;13(4):294-299.
[2]. Eleftherios Michailidis, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. J Biol Chem. 2014 Aug 29;289(35):24533-48.
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