ELOVL6-IN-4 |
| Catalog No.GC71211 |
ELOVL6-IN-4는 사람과 마우스 ELOVL6에 대해 각각 79 nM 및 94 nM의 IC50s를 갖는 강력한, 선택적 및 경구 활성 긴 사슬 지방산 elongase 6 (ELOVL6) 억제제입니다.
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Cas No.: 1170321-92-2
Sample solution is provided at 25 µL, 10mM.
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ELOVL6-IN-4 (compound 1w) potently reduced the elongation index in mouse hepatocyte cells H2.35, with an IC50 of 30 nM.
ELOVL6-IN-4 (compound 1w; 1-10 mg/kg; oral administration; once) potently and dose-dependently suppresses the elongation index in the liver in mice[1].
References:
[1]. Tsuyoshi Nagase, et al. Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009 Jul 23;52(14):4111-4.
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