ESI-08 |
| Catalog No.GC66473 |
ESI-08은 강력하고 선택적인 EPAC 길항제로서 EPAC1 및 EPAC2(IC50 of 8.4 μM) 활성을 완전히 억제할 수 있습니다. 821d96072c2d58d8970e76f526b0f6b8ESI-08은 cAMP에 의한 EPAC 활성화를 선택적으로 차단하지만 cAMP에 의한 PKA 활성화는 억제하지 않습니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 301177-43-5
Sample solution is provided at 25 µL, 10mM.
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IC50: 8.4 μM (EPAC2)[1]
EPAC1[1]
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].
Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].
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