Etilevodopa hydrochloride |
| Catalog No.GC39757 |
레보도파의 에틸 에스테르 전구약물인 에틸레보도파(L-도파 에틸 에스테르) 염산염은 위장관에서 비특이적 에스테라제에 의해 레보도파와 에탄올로 빠르게 가수분해됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 39740-30-2
Sample solution is provided at 25 µL, 10mM.
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Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3].
[1]. Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6. [2]. Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6. [3]. Haddad F, et al. Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease. Molecules. 2017 Dec 25;23(1). pii: E40.
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