[8]-Shogaol |
| Catalog No.GC35013 |
생강의 매운 페놀 화합물 중 하나인 쇼가올은 항혈소판 활성(IC50=5μM)을 나타내고 COX-2(IC50=17.5μM)를 억제합니다. [8]-Shogaol은 인간 백혈병 세포에서 세포 사멸을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
![[8]-Shogaol Chemical Structure](/media/struct/GC3/GC35013.png "[8]-Shogaol Chemical Structure")
Cas No.: 36700-45-5
Sample solution is provided at 25 µL, 10mM.
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[8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells[1][2][3][4]. COX-2|17.5 μM (IC50)
[1]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54. [2]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [3]. Nurtjahja-Tjendraputra E, et al. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111(4-5):259-65. [4]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54.
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