Aristolactam I |
| Catalog No.GC35388 |
Aristololactam I(AL-I)은 Aristolochic acid I(AA-I)의 주요 대사산물로 신장 손상을 일으키는 과정에 참여합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 13395-02-3
Sample solution is provided at 25 µL, 10mM.
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Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1].
[1]. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7.
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