E3 ligase Ligand 12 (Synonyms: E3 ligase Ligand 12) |
| Catalog No.GC35926 |
E3 리가제 리간드 12는 LCL161 유도체 기반 IAP 리간드입니다. E3 리가제 리간드 12는 링커에 의해 단백질용 ABL 리간드에 연결되어 SNIPER를 형성할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095244-42-9
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 12 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 12 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
| Cas No. | 2095244-42-9 | SDF | |
| Synonyms | E3 ligase Ligand 12 | ||
| Canonical SMILES | OC1=CC(C(C2=CSC([C@H]3N(CCC3)C([C@@H](NC([C@@H](N(C(OC(C)(C)C)=O)C)C)=O)C4CCCCC4)=O)=N2)=O)=CC=C1 | ||
| Formula | C31H42N4O6S | M.Wt | 598.75 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.6701 mL | 8.3507 mL | 16.7015 mL |
| 5 mM | 0.334 mL | 1.6701 mL | 3.3403 mL |
| 10 mM | 0.167 mL | 0.8351 mL | 1.6701 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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