E3 ligase Ligand-Linker Conjugates 49 (Synonyms: Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49) |
| Catalog No.GC35956 |
E3 리가제 리간드-링커 접합체 49는 합성된 E3 리가제 리간드-링커 접합체로, 포말리도마이드 기반 세레블론 리간드와 PROTAC 기술에 사용되는 링커를 통합합니다.
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Cas No.: 2351103-63-2
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand-Linker Conjugates 49 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 49 can be used to design PROTAC degrader. Cereblon
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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