FPR Agonist 43 (Synonyms: FPR Agonist 43) |
| Catalog No.GC36075 |
FPR 작용제 43(화합물 43)은 이중 포르밀 펩티드 수용체 1(FPR1) 및 포르밀 펩티드 수용체 2(FPR2)/ALX 작용제입니다.
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Cas No.: 903895-98-7
Sample solution is provided at 25 µL, 10mM.
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FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2]. FPR1, FPR2/ALX[1]
FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells[1]. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM)[1].FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells[2]. Cell Viability Assay[1] Cell Line: Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors
[1]. PlanagumÀ A, et al. Lack of activity of 15-epi-lipoxin A? on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. Clin Exp Immunol. 2013 Aug;173(2):298-309. [2]. Forsman H, et al. What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4• Scand J Immunol. 2011 Sep;74(3):227-234.
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