J30-8 |
| Catalog No.GC36359 |
J30-8은 IC50이 40nM인 c-Jun N-말단 키나제 3(JNK3)의 강력한 동형 선택적 억제제이며 JNK1α1 및 JNK2α2에 대해 2500배 동형 선택성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2366255-71-0
Sample solution is provided at 25 µL, 10mM.
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J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1]. JNK3|40 nM (IC50)
[1]. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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