LY2812223 |
| Catalog No.GC36506 |
LY2812223은 mGlu2 및 mGlu3에 대한 mGlu2 결합 친화도(각각 Ki=144 nM 및 156 nM)를 갖는 매우 강력하고 기능적으로 선택적인 mGlu2 수용체 작용제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1311385-20-2
Sample solution is provided at 25 µL, 10mM.
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LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively)[1]. mGluR2|144 nM (Ki)|mGluR3|156 nM (Ki)
[1]. Monn JA, et al. Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58(18):7526-48.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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