PAT-048 |
| Catalog No.GC36859 |
PAT-048은 강력하고 선택적이며 경구 활성인 오토탁신 억제제이며 IL-6 mRNA 발현을 억제하지만 폐 섬유증 모델에서 오토탁신 단백질 및 폐 리소포스파티딘산(LPA) 생산에는 영향을 미치지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1359983-15-5
Sample solution is provided at 25 µL, 10mM.
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PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo[1][2]. IC50: 20 nM (Autotaxin, in mouse plasma)[1] IC90: 200 nM (Autotaxin, in mouse plasma)[1]
[1]. Castelino FV, et al. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974. [2]. Black KE, et al. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 Jun;30(6):2435-50.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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