ROR agonist-1 |
Catalog No.GC37556 |
ROR 작용제-1은 pIC50이 7.5인 인간 1차 TH17 세포로부터 IL-17A 생산을 억제하는 레티노산 수용체 관련 고아 수용체 C2(RORC2)의 강력하고 경구 생체이용 가능한 역작용제입니다.
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Cas No.: 2361528-74-5
Sample solution is provided at 25 µL, 10mM.
ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1]. pIC 50: 7.5 (human primary TH 17 cells)[1]
[1]. von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10(6):972-977.
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