SNIPER(ER)-110 |
| Catalog No.GC37657 |
SNIPER(ER)-110은 링커로 연결된 IAP 리간드와 에스트로겐 리간드로 구성됩니다. SNIPER(ER)-51은 4시간 및 48시간 후 각각 <3 nM 및 7.7 nM의 DC50으로 에스트로겐 수용체(ER) 단백질 분해를 유도합니다.
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Cas No.: 2241690-03-7
Sample solution is provided at 25 µL, 10mM.
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SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].
[1]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.
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