TH287 hydrochloride |
| Catalog No.GC37775 |
TH287 염산염은 IC50이 0.8nM인 MTH1의 강력하고 선택적인 억제제입니다. TH287 염산염은 100μM에서 MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase 및 ITPA에 대한 관련 억제 없이 MTH1에 대해 매우 선택적입니다. TH287 염산염은 암 연구를 위한 화학요법제로 작용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638211-05-8
Sample solution is provided at 25 µL, 10mM.
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TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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