TAO Kinase inhibitor 1 (Synonyms: CP 43) |
| Catalog No.GC38057 |
TAO 키나제 억제제 1(화합물 43)은 TAOK1 및 2에 대해 각각 11~15nM의 IC50을 갖는 선택적 ATP-경쟁 천개 아미노산 키나제(TAOK) 억제제입니다. TAO Kinase inhibitor 1은 유사분열을 지연시키고 유사분열 세포사를 유도합니다.
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Cas No.: 850467-66-2
Sample solution is provided at 25 µL, 10mM.
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TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death[1].
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells[1].
[1]. Koo CY, et al. Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.
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