BPK-29 hydrochloride |
| Catalog No.GC38643 |
BPK-29 염산염은 C274를 공유적으로 변형하여 비정형 희귀 핵 수용체 NR0B1-단백질(예: RBM45 및 SNW1) 상호작용을 방해하는 특정 리간드입니다. BPK-29 염산염은 KEAP1 돌연변이 암 세포의 고정 독립적인 성장을 손상시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2444815-73-8
Sample solution is provided at 25 µL, 10mM.
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BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 hydrochloride impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].
BPK-29 hydrochloride substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].
[1]. Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171(3):696-709.e23.
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