SMCC (Synonyms: NSC 344483, Succinimidyl 4-(N-maleimidomethyl)cyclohexan-1-carboxylate) |
| Catalog No.GC38695 |
SMCC는 단백질 가교제입니다. SMCC 결합 항원 결합 비장 세포는 항원 특이적 면역 반응을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64987-85-5
Sample solution is provided at 25 µL, 10mM.
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SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses[1].
SMCC or sulfo-SMCC can use to conjugate keyhole limpet hemocyanin (KLH) and ovalbumin (OVA). In the the conjugation system, 300 μl KLH or OVA (3 mg) and 30 μl SMCC or Sulfo-SMCC (the final concentration of 0.1 mM) are added in PBS with final volume of 3 ml[1].
Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice[1].
[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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