>>Rhamnazin

Rhamnazin

Catalog No.GF03629

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Rhamnazin Chemical Structure

Cas No.: 552-54-5

Size 가격 재고 수량
5mg
US$564.00
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products
Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC50 of 4.68 渭M against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy. Rhamnazin shows antioxidant and anti-inflammatory properties.

Rhamnazin (5-40 渭M) inhibits proliferation, migration and tube formation of HUVECs induced by VEGF[1].
Rhamnazin (0-20 渭M) attenuates VEGFR-2 tyrosine kinase activity and VEGFR-2 signaling pathway[1].
Rhamnazin (0-40 渭M; 24 h) inhibits the proliferation and VEGFR2 signaling pathway of breast cancer cells[1].

Rhamnazin (200 mg/kg; i.g.; daily for 25 days) inhibits breast cancer growth and angiogenesis in mice[1].
Rhamnazin (5-20 mg/kg; i.p.; once) shows strong antioxidant and anti-inflammatory properties in the rat acute lung injury model[2].

[1]. Yu Y, et al. Rhamnazin, a novel inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy. Biochem Biophys Res Commun. 2015 Mar 20;458(4):913-9. 

[2]. Wu G, et al. ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF RHAMNAZIN ON LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY AND INFLAMMATION IN RATS. Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):201-212. 

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