>>Gymnestrogenin

Gymnestrogenin

Catalog No.GF11070

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Gymnestrogenin Chemical Structure

Cas No.: 19942-02-0

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10mg
US$420.00
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 渭M for LXR伪 and LXR尾 transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression.

Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells[2].

[1]. St枚cklin W, et al. [Gymnestrogenin, a new pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br]. Helv Chim Acta. 1968;51(6):1235-42. 

[2]. Renga B, et al. Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists. Steroids. 2015 Apr;96:121-31. 

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