GGTI 286 (trifluoroacetate salt) |
| Catalog No.GC43749 |
GGTI 286 is an inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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GGTI 286 is an inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). It also inhibits geranylgeranylation of oncogenic K-Ras4B in NIH3T3 cells (IC50 = 2 μM) and blocks K-Ras4B-induced activation of MAP kinase (IC50 = 1 μM). GGTI 286 (2.5-50 μM) is cytotoxic to RPMI-8226, H929, and U266 multiple myeloma cells in a concentration-dependent manner. It also reduces angiotensin II-induced collagen mRNA and protein production in rat cardiac fibroblasts.
| Cas No. | SDF | ||
| Canonical SMILES | SC[C@H](N)CNC1=CC(C2=CC=CC=C2)=C(C(N[C@@H](CC(C)C)C(OC)=O)=O)C=C1.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F | ||
| Formula | C23H31N3O3S•2CF3COOH | M.Wt | 657.6 |
| Solubility | DMF: 10 mg/ml,DMSO: 20 mg/ml,Ethanol: 2 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5207 mL | 7.6034 mL | 15.2068 mL |
| 5 mM | 0.3041 mL | 1.5207 mL | 3.0414 mL |
| 10 mM | 0.1521 mL | 0.7603 mL | 1.5207 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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