(Gly14)-Humanin (human) (acetate) |
| Catalog No.GC72216 |
(Gly14)-Humanin (human) (acetate) 는 Humanin의 유사 물질로 이 중 14 번째 아미노산 실크 아미노산이 글리 (Gly) 로 대체되었습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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(Gly14)-Humanin (human) acetate (0.1-10 μM; 72 hours) significantly increases cell viability, reduced nuclear fluorescence of HUVECs, the levels of cleaved PARP, ROS formation and the ratio of bax/bcl-2 compared with treatment with high glucose (HG) for 72h. And reduces mRNA level of bax and increases mRNA level of bcl-2[1].
(Gly14)-Humanin (human) acetate acetate (0.1 μg/5 μL; i.c.v.; once) decreases cells with plasmalemma permeability in the injured cortex and hippocampus, reduces brain lesion volume, improves motor performance and ameliorates performance in the Morris water maze test[2].
References:
[1]. Ying Xie, et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6.
[2]. T Wang, et al. [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 2013 Feb 12;231:70-81.
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