GNE 220 Hydrochloride |
| Catalog No.GC34208 |
GNE 220(염산염)은 IC50이 7nM인 강력하고 선택적인 MAP4K4 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2448286-21-1
Sample solution is provided at 25 µL, 10mM.
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GNE 220 (Hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM.
GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs)[1].
[1]. Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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