GSK-J5 (hydrochloride) |
Catalog No.GC43794 |
GSK-J5(염산염)는 비활성인 GSK J2의 세포 투과성 에스테르 유도체입니다. GSK-J5(염산염)도 GSK-J4의 이성질체이며 종종 음성기로 사용됩니다.
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Cas No.: 1797983-32-4
Sample solution is provided at 25 µL, 10mM.
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.
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