Guvacine |
| Catalog No.GC60890 |
Areca catechu의 견과류에서 발견되는 알칼로이드인 구바신은 강력한 GABA uptakp 억제제입니다.
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Cas No.: 498-96-4
Sample solution is provided at 25 µL, 10mM.
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Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].
[1]. L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
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