HDAC8-IN-1 (Synonyms: MDK-7933) |
| Catalog No.GC19189 |
HDAC8-IN-1은 IC50이 27.2nM인 HDAC8 억제제입니다.
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Cas No.: 1417997-93-3
Sample solution is provided at 25 µL, 10mM.
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HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].
References:
[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.
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